Anti-skin Aging Potential of Sargassum thunbergii Ethanolic Extract: Antioxidant, Anti-inflammatory, and Antiwrinkle Effects on L929 Fibroblast Cells

Table 2

The Box-Behnken design matrix for the coded variables.

Experiment run	Standard order	Ratio of solid to liquid (g/mL)	Ethanol concentration (%)	Extraction time (min)	Extraction rate (%)
1	15	20	40	30	1.61
2	5	15	40	20	1.40
3	11	20	30	40	1.50
4	4	25	50	30	1.53
5	1	15	30	30	1.29
6	7	15	40	40	1.54
7	9	20	30	20	1.35
8	8	25	40	40	1.71
9	13	20	40	30	1.61
10	3	15	50	30	1.44
11	14	20	40	30	1.57
12	2	25	30	30	1.48
13	6	25	40	20	1.49
14	16	20	40	30	1.60
15	12	20	50	40	1.52
16	10	20	50	20	1.38
17	17	20	40	30	1.58