The Evaluation of the Role of Beta-Hydroxy Fatty Acids on Chronic Inflammation and Insulin Resistance

Soydan, A. S.; Dokmetas, H. S.; Cetin, M.; Koyuncu, A.; Kaptanoglu, E.; Elden, H.

doi:https://doi.org/10.1155/MI/2006/64980

Mediators of Inflammation

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Research Communication | Open Access

Volume 2006 | Article ID 064980 | https://doi.org/10.1155/MI/2006/64980

The Evaluation of the Role of Beta-Hydroxy Fatty Acids on Chronic Inflammation and Insulin Resistance

A. S. Soydan,¹H. S. Dokmetas,²M. Cetin,³A. Koyuncu,⁴E. Kaptanoglu,⁵and H. Elden⁵

Received09 May 2006

Revised19 Jul 2006

Accepted07 Aug 2006

Published19 Sept 2006

Abstract

β-hydroxy fatty acids are a major component of lipid A moiety of lipopolysaccaride. We aimed to investigate the role of free β-hydroxy fatty acids on inflammation, as well as to evaluate their effects on cytokine release from human blood cells, and whether they exist in plasma of patients with chronic inflammatory diseases with/without insulin resistance. Peripheral venous blood was incubated with β-hydroxy lauric and β-hydroxy myristic acids (each 100 ng, 1 μg, 10 μg/mL) up to 24 hours. Cytokines were measured from culture media and plasma. Free fatty acids and biochemical parameters were also measured from patients' plasma. Only β-hydroxy lauric acid significantly stimulated interleukin-6 production at 10 μg/mL compared to control (533.9±218.1 versus 438.3±219.6 pg/mL, P<.05). However, free β-hydroxy lauric and myristic acids were not found in patients' plasma. Therefore, free β-hydroxy lauric and myristic acids do not seem to have a role on sterile inflammation in chronic inflammatory diseases associated with insulin resistance.

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Copyright © 2006 A. S. Soydan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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