Urinary Eosinophil Protein X in Children with Atopic Asthma

Nuijsink, M.; Hop, W. C. J.; Sterk, P. J.; Duiverman, E. J.; Hiemstra, P. S.; de Jongste, J. C.

doi:https://doi.org/10.1155/2007/49240

Mediators of Inflammation

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Clinical Study | Open Access

Volume 2007 | Article ID 049240 | https://doi.org/10.1155/2007/49240

Urinary Eosinophil Protein X in Children with Atopic Asthma

M. Nuijsink,¹W. C. J. Hop,²P. J. Sterk,³E. J. Duiverman,⁴P. S. Hiemstra,⁵and J. C. de Jongste⁶

Received01 Sept 2006

Revised26 Feb 2007

Accepted12 Mar 2007

Published12 Jun 2007

Abstract

The aim of this study was to investigate the relationship between urinary eosinophil protein X (uEPX) and asthma symptoms, lung function, and other markers of eosinophilic airway inflammation in asthmatic school children. Methods. A cross-sectional study was performed in 180 steroid dependent atopic children with stable moderately severe asthma, who were stable on 200 or 500μg of fluticasone per day. uEPX was measured in a single sample of urine and was normalized for creatinine concentration (uEPX/c). Symptom scores were kept on a diary card. FEV1 and PD20 methacholine were measured. Sputum induction was performed in 49 and FENO levels measured in 24 children. Results. We found an inverse correlation between uEPX/c and FEV1 (r=−.20, P=.01) and a borderline significant correlation between uEPX/c and PD20 methacholine (r=−.15, P=.06). Symptom score, %eosinophils and ECP in induced sputum and FENO levels did not correlate with uEPX/c. Conclusion. uEPX/c levels did not correlate with established markers of asthma severity and eosinophilic airway inflammation in atopic asthmatic children.

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Copyright © 2007 M. Nuijsink et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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