Mycoplasma genitalium Lipoproteins Induce Human Monocytic Cell Expression of Proinflammatory Cytokines and Apoptosis by Activating Nuclear Factor B
Figure 1
The effect of
different concentrations of LP on the production of TNF- (a), IL-6 (b), and
IL-1 (c) in THP-1 cells. Dose-dependent induction of TNF- (a), IL-6 (b), and IL-1 (c) was seen in THP-1 cells after 24 hours of stimulation with 0.5 to 5 g/mL of LP, 3 g/mL of LP in combination with 25 M PDTC, or 0.1 g/mL LPS. In this experiment THP-1 cells stimulated with aqueous phase were used as the negative control. Proinflammatory cytokine levels were determined by ELISA as indicated in Section 2. The results were representative of three independent experiments.
