The NF-B Inhibitor Curcumin Blocks Sepsis-Induced Muscle Proteolysis
Figure 7
(a) p65 levels determined by Western blotting and (b) p65 activity in the nuclear fraction of extensor digitorum longus muscles from septic rats incubated for 2 hours in the absence or presence of 100 M curcumin.
Results are means ±SEM with in each group. AU: arbitrary units. * versus control by Student’s -test. (c) The effect of the p65 inhibitor PTD-p65-P1 on protein breakdown rates in incubated muscles from septic rats. Muscles were incubated in the presence of 100 M PTD-p65-P1 or 100 M of the inactive peptide PTD as control. Results are means ±SEM with in each group. * versus PTD by Student’s -test.
