Oxymatrine Downregulates TLR4, TLR2, MyD88, and NF-B and Protects Rat Brains against Focal Ischemia
Figure 7
TLR2 expression detected by immunohistochemistry. (a) TLR2 expression in the sham group: TLR2 expression could be observed periodically in the sham group at 24 hours. (b) TLR2 expression in the saline group: TLR2 expression evidently increased in the saline group at 24 hours. Positive cells were defined as presenting buffy grains in cytoplasm. (c) TLR2 expression in the OMT treatment group: TLR2 expression decreased relatively in the OMT treatment group at 24 hours. (d) TLR2 expression in each group at all time points: expression of TLR2 protein was evidently higher in the saline group at 6 hours and lasted up to 48 hours. There was no difference between saline and OMT group at 6 hours. Compared with the saline group at 24 hours and 48 hours, expression of TLR2 protein was lower in the OMT treatment group, and the difference was significant compared with Sham and compared with saline group.
