Leptin Induces an Inflammatory Phenotype in Lean Wistar Rats

<table><i>Leukocyte trafficking in the mesenteric microvasculature</i>. Wistar rats (200–250 g) were subjected to intravital microscopic analysis of leukocyte trafficking in mesenteric postcapillary venules. (a) Occasional rolling and adherent leukocytes were observed in mesenteric venules in saline controls. (b) Mesenteric venules 24 hours after leptin administration (1 mg/kg i.v.) displayed a marked enhancement in leukocyte trafficking as denoted by arrows. (c) Summary of control and leptin-stimulated leukocyte trafficking. Data are mean ± SEM analyzed by one-way ANOVA; <svg height="13.75" id="M20" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 7.7375002 13.75" width="7.7375002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,.062,5.525)"><path d="M471 153q-22 -15 -61 -13q-25 31 -45.5 49.5t-56.5 41.5q4 -71 28 -134q-17 -33 -42 -46q-24 12 -42 46q24 63 28 134q-36 -23 -56.5 -41.5t-45.5 -49.5q-36 -2 -61 13q0 28 19 59q65 10 130 43q-65 33 -130 43q-19 31 -19 59q22 15 61 13q25 -31 45.5 -49.5t56.5 -41.5
q-4 71 -28 134q17 33 42 46q24 -12 42 -46q-24 -63 -28 -134q36 23 56.5 41.5t45.5 49.5q36 2 61 -13q0 -28 -19 -59q-65 -10 -130 -43q65 -33 130 -43q19 -31 19 -59z" id="x2217"></path></g>
</svg><i>P </i>&lt; .05 compared to control.</table>

Mediators of Inflammation

Leptin Induces an Inflammatory Phenotype in Lean Wistar Rats

Figure 1