The Effects of Interleukin-1β in Tumor Necrosis Factor-α-Induced Acute Pulmonary Inflammation in Mice

Table 1

Cell count and differential of bronchoalveolar lavage harvested six hours after oropharyngeal delivery of TNF alpha or control saline. BAL: bronchoalveolar lavage; Lymphs: lymphocytes. Treatment groups represent 8–15 mice/group.^∗𝑃≤.05 TNF versus saline, C57BL6/J treatment groups; ^‡P ≤ .05 IT TNF versus Saline, IL𝛽^−/− treatment groups; ^#𝑃≤.05 IT TNF, IL-1𝛽^−/− versus WT treatment groups. Values are means ± SEM,𝑛=8−15mice.

	Cell type
Group	BAL Cell Count (×10^4/mL)	% Macrophages	% Neutrophils	% Lymphs	Macrophage # (×10^4/mL)	Neutrophil # (×10^4/mL)	Lymph # (×10^4/mL)
Saline, C57BL6/J	41.3±6.2	96.0±1.2	2.1±0.6	1.9±0.9	39.9±6.2	0.86±0.3	0.57±0.3
TNF, C57BL6/J	26.0±2.8^∗	89.7±2.0^∗	8.5±2.0^∗	1.9±0.7	29.7±5.9	2.23±0.4^∗	0.65±0.3
Saline, IL-1𝛽^−/−	57.0±7.2	97.7±0.8	1.5±0.7	0.8±0.3	56.0±7.4	0.66±0.3	0.30±0.1
TNF, IL-1𝛽^−/−	39.8±5.4^‡#	97.0±0.8^#	1.6±0.5^#	1.4±0.6	38.7±5.4	0.65±0.3^#	0.46±0.2