Oxidative Damage in Lymphocytes of Copper Smelter Workers Correlated to Higher Levels of Excreted Arsenic

Figure 1

Comparative effect of arsenic exposure on the proliferation of lymphocytes isolated from low- and high-As-exposure human populations. Correlation of lymphocyte proliferation and urinary excretion of As from highly As-exposed population. (a) Proliferation was assessed by comparison of ³H-Thymidine incorporation ([³H]-TdR, cpm) in lymphocytes isolated from the low-As-exposure group (control group, 𝑛=31) and from the high-As-exposure group (𝑛=50). Statistically significant differences were found between the two groups (U-Mann-Whitney test 𝑃=.0138). (b) Relationship between ³H-Thymidine incorporation and arsenic concentration in urine (ppm) of the highly exposed population (𝑛=50). Association between the two variables was determined by 𝑅-Pearson (𝑃=.002).

(a)

(b)