Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)

Table 2

Number of rats exhibiting the different pathology scores observed in endocrine (A) and exocrine (B) pancreas.

A-Endocrine pancreas lesions
Evaluated	Inflammatory				Fibrosis				Intra islet				Congestion
parameters	Infiltrate								Vacuolation
Score	0	1	2	3	0	1	2	3	0	1	2	3	0	1	2	3
Groups ($n=8$, each)
ZDF (+/+) vehicle	7	1	0	0	6	2	0	0	8	0	0	0	8	0	0	0
ZDF (fa/fa) vehicle	0	0	5	3	0	1	1	6	2	0	6	0	7	0	1	0
ZDF (fa/fa) sitagliptin	1	7	0	0	0	5	3	0	4	3	1	0	8	0	0	0
B – Exocrine pancreas lesions
Evaluated	Inflammatory						Fibrosis						Congestion
parameters	Infiltrate
Score	0	1	2	3			0	1	2	3			0	1	2	3
Groups ($n=8$, each)
ZDF (+/+) vehicle	8	0	0	0			7	1	0	0			8	0	0	0
ZDF (fa/fa) vehicle	0	3	5	0			0	3	3	2			2	6	0	0
ZDF (fa/fa) sitagliptin	0	4	4	0			6	1	1	0			4	4	0	0

ZDF, Zucker diabetic fatty.