High-Mobility Group Box-1 Protein Serum Levels Do Not Reflect Monocytic Function in Patients with Sepsis-Induced Immunosuppression

Figure 1

Course of HMGB-1 serum levels (ng/mL) from baseline until study day 9 (after immunotherapy) for GM-CSF (squares) and placebo-treated (circles) individuals. ${}_{}{}^{*}P\le .05\text{,}$${}_{}{}^{**}P\le .01$ (GM-CSF-treated individuals); ##$P\le .01$ between the two groups at the same day of assessment. Means $\pm$ SEM are given, paired and unpaired samples t-test, as appropriate.