Ivabradine reduces SDF-1 and RANTES-induced CD4-positive lymphocyte migration. (a) Human CD4-positive cells were pretreated with ivabradine for 15 minutes at concentrations indicated before migration experiments using SDF-1 (100 ng/mL) were performed in a modified Boyden chamber. Data are expressed as fold induction compared to SDF-1-stimulated cells. Bars represent mean ± SD (); compared to chemokine-stimulated cells. (b) Human CD4-positive lymphocytes were pretreated with ivabradine for 15 minutes at concentrations indicated before migration experiments using RANTES (100 pg/ml) were performed. Data are expressed as fold induction of chemokine-stimulated cells. Bars represent mean ± SD (); * compared to chemokine-stimulated cells.
