Ivabradine Reduces Chemokine-Induced CD4-Positive Lymphocyte Migration

Figure 4

Ivabradine reduces actin polymerisation in CD4-positive lymphocytes. (a) Isolated lymphocytes were pretreated with ivabradine (𝑛=5) for 15 min before stimulation with SDF-1. Actin polymerisation was determined by flow cytometry at times indicated. Lower panel represents statistical analysis for the four timepoints indicated. Bars represent mean ± SD; 𝑛=5; ^#𝑃<.05; *𝑃<.01 compared to SDF-1-stimulated cells.