Tropism, Cytotoxicity, and Inflammatory Properties of Two Envelope Genes of Murine Leukemia Virus Type-Endogenous Retroviruses of C57BL/6J Mice

Table 1

Tropism trait and infectivity of the ENV_OV1 and ENV_OV2 polypeptides. Infection titer unit (U/mL): number of LacZ positive cells per mL of supernatant containing virus particles. ND: not detectable.

Cell lines			Infection titer (U/mL)
	ENVOV1	ENVOV2	pEco	pAmpho	p10A1	pVSVG
Human
HeLa	1.6 × 10^1	1.5 × 10^4	ND	2.2 × 10^4	2.2 × 10^4	4.7 × 10^4
tsA201	3.1 × 10^1	2.0 × 10^6	ND	2.8 × 10^6	1.4 × 10^6	8 × 10^6
HCT116	2.0 × 10^1	3.2 × 10^4	ND	2.7 × 10^4	4.0 × 10^4	1.7 × 10^4
Nonhuman primate
COS-1	4.0 × 10^1	2.0 × 10^5	ND	2.0 × 10^5	3.8 × 10^5	1.2 × 10^5
COS-7	6.9 × 10^1	8.4 × 10^5	ND	1.3 × 10^6	3.2 × 10^6	5.2 × 10^6
Mouse
NIH3T3	2.0 × 10^1	9.5 × 10^4	4.5 × 10^5	1.7 × 10^4	3.3 × 10^4	1.4 × 10^4
Neuro2a	ND	2.1 × 10^4	4.4 × 10^3	2.7 × 10^3	2.1 × 10^3	4.8 × 10^3
Dog
MDCK	ND	3.2 × 10^1	ND	3.2 × 10^2	2.6 × 10^2	1.2 × 10^2