Pro- and Anti-Inflammatory Cytokines during Immune Stimulation: Modulation of Iron Status and Red Blood Cell Profile

Table 7

Forward stepwise regression for serum iron markers and red blood cell indices in terms of pro- and anti-inflammatory cytokines (*significant, ^√non-significant, and coefficient values).

	INF-γ	TNF-α	Il-1β	Il-6	Il-12	Il-2	Il-8	GM-CSF	Il-4	Il-5	TGF- β	Il-10	R^2	Adjusted R^2
Serum iron													0.000	0.000
			√				*				*		0.51	0.45
Serum transferrin			0.05				-0.09				0.39
											*		0.17	0.13
Transferrin saturation											-0.61
	√			√	*		√		√	√	*	√	0.73	0.62
Serum ferritin	0.16			-0.24	-0.46		0.32		0.58	0.45	-0.81	0.33
		√			*		√	√			*		0.61	0.52
Transferrin/log ferritin		-0.38			0.21		-0.12	0.09			0.38
Soluble transferrin	√						√	√					0.25	0.16
receptor	0.11						-0.12	0.13
Soluble transferrin		*					√			*	√		0.39	0.28
receptor/log ferritin		0.50					-0.13			-0.37	0.31
											*	*	0.28	0.23
Red blood cell count											0.28	-0.13
											√	*	0.29	0.23
Haemoglobin											0.19	-0.17
			√								√	*	0.36	0.28
Haematocrit			-0.06								0.22	-0.15
									*				0.22	0.19
Mean corpuscular volume									-0.08
Mean corpuscular									*	√	√		0.28	0.19
haemoglobin									-0.08	-0.06	-0.10
Mean corpuscular					√						*	√	0.33	0.24
haemoglobin concentration					0.02						-0.04	-0.01
Red blood cell								√				*	0.29	0.23
distribution width								0.05				0.10