Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4/NF-B Pathway after Traumatic Brain Injury in the Rat
Figure 5
Expression of HMGB1 and TLR4 protein in the rat brain of the Sham group, TBI group, and TBI + EP group. Upper panel represents autoradiogram of the HMGB1 and TLR4 protein expression by Western blot. Bottom panel is quantitative analysis of the Western blot results for the expression of HMGB1 and TLR4 protein. TBI induced a marked increase of HMGB1 and TLR4 protein expression in the brain tissue surrounding the contusion cortex compared to the Sham group (). The HMGB1 and TLR4 protein expressions were significantly downregulated compared to the TBI group after EP treatment (). Bars represent as mean ± SEM; , each group; **P versus Sham group, #P versus TBI group.
