Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4/NF-B Pathway after Traumatic Brain Injury in the Rat
Figure 9
TUNEL immunohistochemistry staining of the injured cortex in Sham group, TBI group, and TBI + EP group. (a) Sham group rats showed few TUNEL apoptotic cells; (b) TBI group rats showed more TUNEL apoptotic cells stained as brown; (c) TBI + EP group rats showed less TUNEL apoptotic cells than TBI group (scale bars, 50 μm). (d) EP administration significantly decreased the apoptotic index in rat injured brain following TBI. Bars represent as mean ± SEM; , each group; **P versus Sham group, #P versus TBI group.
