LPS Counter Regulates RNA Expression of Extracellular Proteases and Their Inhibitors in Murine Macrophages
Figure 3
The RNA expression of genes encoding MMP inhibitors are downregulated in activated macrophages. Whereas LPS led to a general increase in MMP gene expression, the genes encoding the MMP inhibitors TIMP1 and TIMP2 were downregulated in LPS-stimulated cultures compared to vehicle-treated control cultures. The difference in the basal RNA expression levels (0 hours) between Timp1 and Timp2 differed by 128 folds. Data were analyzed by a two-tailed Mann-Whitney test. * between LPS and vehicle-stimulated cultures. for all groups.
