The Deleterious Influence of Tenofovir-Based Therapies on the Progression of Atherosclerosis in HIV-Infected Patients
Table 1
Characteristics of the control group () and HIV-infected patients () at baseline and at follow-up by treatment group.
HIV-infected patients
Characteristics
Control group
ABC-3TC ()
TDF-FTC ()
Baseline
Followup
Baseline
Followup
Gender, male (%)
135 (67)
24 (68)
NA
20 (62)
NA
Age, years
39.1 (0.4)
38.9 (0.6)
NA
38.3 (0.6)
NA
BMI, kg/m2
26.2 (0.2)
23.31 (0.2)
23.52 (0.4)
23.21 (0.2)
23.82 (0.3)
Systolic blood pressure, mm Hg
119.14 (1.7)
118.04 (1.4)
120.46 (1.5)
118.45 (1.5)
121.01 (1.5)
Diastolic blood pressure, mm Hg
77.36 (1.2)
75.96 (1.1)
78.35 (1.9)
76.26 (1.4)
78.01 (0.97)
Smoking, n (%)
90 (39.7)a
23 (66)
21 (62)
20 (62)
19 (59)
Total WBC count, cells x 109/L
NA
4.27 (1.6)
4.73 (2.1)
4.50 (1.9)
4.83 (2.0)
CD4+ T cell count, cells/μL
NA
458.97 (20.0)b
526.33 (24.8)
469.87 (20.2)b
520.25 (26.8)
Total cholesterol, mmol/L
5.02 (0.3)
5.06 (0.1)b
4.90 (0.1)
4.99 (0.1)b
4.80 (0.1)
HDL cholesterol, mmol/L
1.47 (0.1)a
1.17 (0.04)
1.19 (0.04)
1.18 (0.04)
1.19 (0.03)
LDL cholesterol, mmol/L
2.78 (0.3)
2.82 (0.1)b
2.68 (0.1)
2.88 (0.1)b
2.58 (0.1)
Triglycerides, mmol/L
1.1 (0.3)
2.50 (0.2)
2.53 (0.2)
2.49 (0.2)
2.59 (0.2)
Glucose, mmol/L
4.91 (0.4)
5.42 (0.1)
5.40 (0.2)
5.42 (0.2)
5.35 (0.1)
CRP, mg/L
0.83 (0.1)a
4.67 (3.4)
4.81 (3.9)
4.85 (3.2)
4.76 (4.2)
MCP-1, pg/mL
427.9 (149.7)a
830.8 (193.3)b
555.1 (96.2)
846.4 (198.1)
826.3 (113.9)
sCD40L, ng/mL
2.03 (0.2)
1.64 (0.4)
1.56 (0.3)
1.60 (0.5)
1.71 (0.7)
tPA, ng/mL
5.63 (0.5)a
9.71 (0.86)b
6.60 (0.64)
9.45 (0.79)b
6.10 (0.64)
IL-6, pg/mL
3.29 (0.8)a
7.19 (1.3)b
6.19 (1.3)
7.11 (1.5)b
6.30 (1.1)
IL-8, pg/mL
14.88 (6.1)
36.38 (5.2)
32.92 (8.1)
36.99 (7.3)
34.01 (7.9)
P-Selectin, pg/mL
185.23 (50.4)
205.19 (88.8)
199.05 (70.9)
211.11 (79.8)
200.35 (72.6)
Data are the mean (SEM) unless otherwise indicated. a with respect to baseline values of all HIV-infected patients; b with respect to follow-up values. BMI, body-mass index; NA, not applicable; WBC: white blood cells.
