Serum IL-18 Is Closely Associated with Renal Tubulointerstitial Injury and Predicts Renal Prognosis in IgA Nephropathy

Table 6

Cox Regression analysis using to evaluate risk factor for renal function deterioration in patients with IgA nephropathy.

Parameter	𝛽	t	𝑃 value
TID score	1.96	3.69	0.001
sIL-18 (pg/mL)	1.98	2.77	0.003
Baseline Scr (μmol/L)	0.09	0.19	0.017
eGFR (mL/min/1.73 m^2)	−0.05	0.01	0.023
Proteinuia (g/24 h)	2.50	0.33	0.056
Gender	0.56	0.32	0.572
Age (year)	−0.19	−3.98	0.312
Smoke history	0.33	0.41	0.746
SBP (mmHg)	−0.03	−0.27	0.760
DBP (mmHg)	0.02	0.23	0.821
Hemoglobin (g/dL)	0.22	1.43	0.739
sAlb (g/L)	0.002	0.02	0.734
Cholesterol (mmol/L)	0.07	0.59	0.653
Triglyceride (mmol/L)	−0.18	−1.53	0.533
sIgA (g/L)	0.18	1.97	0.812
Hs-CRP (mg/L)	0.13	1.45	0.931
GSS (%)	−0.04	−0.36	0.602