Clinical Study
Picolinic Acid in Patients with Chronic Hepatitis C Infection: A Preliminary Report
Table 3
Clinical and biochemical characteristics of patients with chronic hepatitis C infection (CHC) according to the presence of diabetes.
| | Healthy controls | CHC patients with diabetes | CHC patients without diabetes |
| | (n) | 40 | 22 | 29 | | Male : female ratio | 23 : 17 | 10 : 12 | 12 : 17 | | Age (years) | 32 (19–65) | 46 (21–65) | 45 (18–60) | | BMI (kg/m2) | 28 (22–33) | 27 (23–31) | 25.8 (22–29) | | Glucose (mmol/L) | 4.6 (4.0–5.2) | 7.6**+ (5.7–9.5) | 5.2 (4.7–5.7) | | (%) | — | 7.8+ (5.0–9.8) | 5.4 (5.0–6.0) | | ALT (U/L) | 24 (20–28) | 86** (10–392) | 74* (20–144) | | AST (U/L) | 27 (23–30) | 68* (12–272) | 53* (20–97) | | Albumin (g/L) | 45 (36–57) | 43 (39–44) | 45 (43–48) | | PA (μmol/L) | 0.2 (0.2–1.81) | 1.9**+ (0.8–6.7) | 0.32 (0.2–1.5) | | hsCRP (mg/L) | 1.2 (0.1–4.8) | 3.14*+ (0.36–4.45) | 1.51 (0.22–1.9) | | ESR (mm/h) | 6 (5–7) | 8 (3.5–22) | 6 (5–7) | | PLT (× 109/L) | 200 (150–220) | 205 (158–240) | 207 (161–242) | | WBC (× 109/L) | 4.6 (4.2–5.1) | 6.7*(5.1–8.8) | 5.3 (4.5–7.4) |
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Data reported as median (range). Significance levels between groups: * ; ** versus healthy controls; + versus CHC patients without diabetes. ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; PA, picolinic acid; PLT, platelet; WBC, white blood cells.
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