High-Mobility Group Box 1 Induces Calcineurin-Mediated Cell Hypertrophy in Neonatal Rat Ventricular Myocytes

<table>Effect of different concentrations of HMGB1 (50 to 200 ng/mL) on calcineurin activity and calcineurin A protein expression in NRVMs after 24 hours. (a) Calcineurin activity in NRVMs was determined by a calcineurin assay kit. (b) Expression of calcineurin A protein was determined by Western blot analysis, and the integrated optical density (IOD) of ANP expression bands was analyzed. The bar graph represents three independent experiments. *<svg height="11.375" id="M5" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus control. Ctrl: control group.</table>

Mediators of Inflammation

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Figure 2

Figure 2: High-Mobility Group Box 1 Induces Calcineurin-Mediated Cell Hypertrophy in Neonatal Rat Ventricular Myocytes 