Research Article
The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome
Table 3
Correlation coefficients between circulating Th17, Treg, or ratio and BMI, PSG parameters, and inflammatory cytokines in OSAS patients (
).
| Parameters | Th17 | Treg | Th17/Treg | r | P | r | P | r | P |
| BMI | 0.124 | NS | 0.140 | NS | 0.260 | NS | AHI | 0.284 | NS | −0.290 | NS | 0.321 | 0.029 | Nadir SaO2 (%) | 0.189 | NS | −0.238 | NS | 0.194 | NS | SaO2 < 90% (%TST) | 0.207 | NS | −0.274 | NS | 0.262 | NS | ESS scores | 0.175 | NS | −0.266 | NS | 0.178 | NS | RORγt/GADPH mRNA | 0.483 | 0.001 | −0.114 | NS | 0.076 | NS | Foxp3/GADPH mRNA | −0.234 | NS | 0.435 | 0.003 | −0.053 | NS | IL-10 (pg/mL) | 0.089 | NS | 0.120 | NS | 0.095 | NS | TGF-β 1 (pg/mL) | −0.291 | NS | 0.427 | 0.004 | −0.211 | NS | IL-17 (pg/mL) | 0.525 | <0.001 | −0.224 | NS | 0.288 | NS | IL-6 (pg/mL) | 0.068 | NS | 0.106 | NS | 0.183 | NS | hsCRP (pg/mL) | 0.372 | 0.013 | −0.433 | 0.003 | 0.475 | 0.001 |
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Definition of abbreviations: AHI: apnoea hypopnoea index; BMI: body mass index; hsCRP: high-sensitivity C-reactive protein; ESS: Epworth sleepiness scale; nadir: lowest oxygen saturation recorded; OSAS: obstructive sleep apnoea syndrome; TST: total sleep time.
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