Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension

<table>Effects of MIF inhibition on rat PASMCs proliferation under hypoxia exposure. PASMCs proliferation was measured by MTT (a) and direct cell counting (b). Hypoxia-induced PASMCs proliferation was inhibited by different concentrations of MIF antagonist ISO-1 (10, 50, 100 <i>μ</i>M). <svg height="11.225" id="M19" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus normoxic control; <svg height="19.65" id="M21" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 70.224998 19.65" width="70.224998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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<g transform="matrix(.017,-0,0,-.017,11.575,16.7)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,27.112,15.5)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,41.799,15.5)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,49.959,15.5)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,53.835,15.5)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,61.994,15.5)"><use xlink:href="#x35"></use></g>
</svg> versus vehicle-treated hypoxia group.</table>

Mediators of Inflammation

fig3

Figure 3

Figure 3: Role of Macrophage Migration Inhibitory Factor in the Proliferation of Smooth Muscle Cell in Pulmonary Hypertension 