Peripheral Mechanisms of Dental Pain: The Role of Substance P

Table 1

Key effects of substance P in dental pulp.

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Healthy tissues

 Maintenance of tissue homeostasis [6, 27, 28]

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Inflamed tissues

 Vasodilatatory response [6, 7]

 Histamine release [29]

 Increase in blood flow [29]

 Increase in vascular permeability [29]

 Increase in blood pressure [29]

 Synthesis of proinflammatory cytokines [30, 31]

 Chemotaxis of inflammatory cells [30]

 Sensitisation of nociceptors [7]

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