Activation of Protease-Activated Receptor 2-Mediated Signaling by Mast Cell Tryptase Modulates Cytokine Production in Primary Cultured Astrocytes
Figure 2
Effects of tryptase (Tt) on the generation of reactive oxygen species (ROS) from astrocytes. Astrocytes were exposed to different concentrations of tryptase (0.001, 0.01, 0.1, 1, and 10 μg/mL) in the presence or absence of FSLLRY-NH2 (FS, 400 μM), an antagonist of tryptase at 37°C for 2 h. ROS was presented as changes of DCF fluorescence. Data are presented as the mean ± SEM analyzed from three independent sets of samples. versus control group (Con), versus corresponding tryptase treatment group.
