Activation of Protease-Activated Receptor 2-Mediated Signaling by Mast Cell Tryptase Modulates Cytokine Production in Primary Cultured Astrocytes
Figure 3
Effects of tryptase (Tt) on the secretion of IL-6 (a) and TNF-α (b) from astrocytes. Astrocytes were exposed to different concentrations of tryptase (0.001, 0.01, 0.1, 1, and 10 μg/mL) in the presence or absence of FSLLRY-NH2 (FS, 200 or 400 μM), an antagonist of tryptase at 37°C for 24 h before culture supernatant being collected. Data are presented as the mean ± SEM of four independent experiments. versus control groups (Con), versus corresponding tryptase treatment groups.
