Oncostatin M and TLR-4 Ligand Synergize to Induce MCP-1, IL-6, and VEGF in Human Aortic Adventitial Fibroblasts and Smooth Muscle Cells

<table>MCP-1, IL-6, VEGF, and IL-8 mRNA levels in HAoAFs and HAoSMCs upon LPS and OSM stimulation. HAoAFs ((a)–(d)) and HAoSMCs ((e)–(h)) were stimulated with LPS (10 ng/mL), OSM (5 ng/mL), or LPS/OSM combination. Steady state levels of MCP-1, IL-6, VEGF, and IL-8 mRNA were measured by qRT-PCR 6 hours after stimulation.</table>

Mediators of Inflammation

fig6

Figure 6

Figure 6: Oncostatin M and TLR-4 Ligand Synergize to Induce MCP-1, IL-6, and VEGF in Human Aortic Adventitial Fibroblasts and Smooth Muscle Cells 