|
| Author and reference number | Year | Experimental model | MAPK phosphorylation | Cardiac remodeling |
|
| Okoshi et al. [62] | 2004 | Primary cultures of neonatal rat cardiomyocytes | Increased
P-ERK1/2 | Aldosterone induces hypertrophy through ERK1/2 activation |
|
| Yue et al. [63] | 2000
| Primary cultures of neonatal rat cardiomyocytes | Increased
P-ERK1/2 | ERK1/2 activation mediates endothelin-1- and phenylephrine-induced cardiac hypertrophy |
|
Wang and Proud [64] | 2002 | Adult rat ventricular cardiomyocytes | |
|
| Chen et al. [97] | 2007 | Rat myocardium | Increased P-ERK5; P-STAT-3; P-p38 MAPK | Long-term intermittent hypoxia is associated to induced cardiac hypertrophy through the activation of MAPK pathways |
|
| Takeishi et al. [79] | 2001 | Guinea pigs | Increased
P-ERK1/2, P-p38 MAPK | Chronic pressure-overload and acute mechanical stretch-induced cardiac hypertrophy is mediated by ERK1/2 and p38 MAPK activation |
|
| Esposito et al. [80] | 2010 | Mice left ventricle and white blood cells from mice and
hypertensive patients with controlled blood pressure values | Increased P-ERK1/2, P-p38 MAPK, P-JNK | MAPKs are sensors of pressure overload |
|
| Rose et al. [82] | 1998 | Primary cultures of neonatal rat cardiomyocytes | Increased P-JNK and P-p38 MAPK | JNK activation induces hypertrophy, while concomitant activation of p38 MAPK and JNK inhibits hypertrophic response |
|
| Wang et al. [84] | 1998 | Primary cultures of neonatal rat cardiomyocytes | Increased P-JNK and P-p38 MAPK | JNK induces hypertrophy, while concomitant activation of p38 MAPK and JNK fails to promote hypertrophic response |
|
| Zechner et al. [96] | 1997 | Primary cultures of neonatal rat cardiomyocytes | Increased P-p38 MAPK | Transfection of the cell with constructs activating MAPKs revealed a central role of p38 MAPK activation in cardiac hypertrophy |
|
| Choukroun et al. [98] | 1998 | Primary cultures of neonatal rat cardiomyocytes | Increased SAPK and not P-ERK | In contrast to SAPK, ERK activation is not required for hypertrophic response induced by endothelin |
|
