Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-B, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability
Figure 5
PN decreased mRNA expressions of caspase-1 and NF-κB after MCAO. (b) shows the mRNA expression of caspase-1. Compared with MCAO group, the expression of caspase-1 was significantly decreased in High group 72 h. There is no difference between sham and MCAO group at 24 h. (d) shows the mRNA expression of NF-κB. Compared with MCAO group, the expression of NF-κB was significantly decreased in High group both at 24 h and 72 h, but decreased only at 72 h in Low group versus MCAO group. Representative photographs in ((a) and (c)) show the influence of PN on the mRNA expression of NF-κB and caspase-1 at 72 h.
