Intricacies for Posttranslational Tumor-Targeted Cytokine Gene Therapy
Figure 2
Location of the tumor-targeting sequence affects the induced antitumor response in a tumor histotype-specific manner. The ttIL12-p40 pDNA treatments increased the antitumor activity compared to the wtIL12 pDNA treatments in the 4T1 ((a) primary tumor growth; (b) lung metastases; (c) survival) and B16F10 ((d) primary tumor growth, (e) survival) tumor models. (f) In the SCCVII model, all ttIL12-peptide pDNA treatments significantly extend survival. Black arrows represent treatment dates. # represents compared to all other groups. * represents compared to all other IL12 treatment groups.
