Inhibitory Effect of Natural Anti-Inflammatory Compounds on Cytokines Released by Chronic Venous Disease Patient-Derived Endothelial Cells

Table 2

Baseline release of cytokines/chemokines and growth factors by pathological VEC.

Cytokines/Chemokines	Release levels (pg/mL/24 hours)^a	Limit of detection (pg/mL)
MIP-1𝛼	<OOR	2.9
IL-8	2,616 (3,111.8±2,532.4)	0.4
IL-7	11.6 (16.7±10.1)	1.4
IFN-𝛾	2.1 (2.3±0.9)	0.8
IL-12 (p70)	2.8 (2.8±0.4)	0.6
TNF-𝛼	1.8 (1.6±0.3)	0.7
GM-CSF	8.2 (8.6±5.5)	7.5
IFN-𝛼2	9.1 (9.3±3.7)	2.9
G-CSF	49 (65.9±37)	1.8
IL-1RA	10.4 (11.4±4.2)	8.3
MIP-1𝛽	4 (4.5±2.1)	3.0
VEGF	ND	26.3
EGF	ND	2.8
Eotaxin	10.2 (15.1±8.5)	4.0
MCP-1	8,663 (8,630.1±1,450)	1.9
CXCL10	20.5 (41.6±55)	8.6
PDGF	1,399 (1,494.6±468.9)	2.2
RANTES	31 (33.3±14.9)	1.2

aValues are expressed as median (mean ± SD); <OOR: out (below) of detection range; ND: not determinable because component of the endothelial medium.