Scutellarin Attenuates Hypertension-Induced Expression of Brain Toll-Like Receptor 4/Nuclear Factor Kappa B

Figure 2

Scutellarin decreases the number of activated microglia in brain of hypertension. (a–d) Cluster of differentiation 11b (OX-42) immunostaining for microglia. (e) Quantification of OX-42-positive cells revealed that activated microglia were significantly increased in normal saline (NS) rats compared with the sham group, and treatment with scutellarin significantly reduced these numbers in a dose-dependent manner. ^∗𝑃<0.001 versus sham group; ^◆𝑃<0.001 versus NS group; ^&𝑃<0.001 versus low-dose group. Scale bar = 100 μm.

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