Scutellarin Attenuates Hypertension-Induced Expression of Brain Toll-Like Receptor 4/Nuclear Factor Kappa B

Figure 5

Scutellarin treatment upregulated Mcl1 and suppressed Bax, caspase-3 p17 expression. Western immunoblot analysis of protein levels of (a) Mcl1, (b) Bax, and (c) cleavedcaspase-3 p17 in the rat cortex and striatum. Scutellarin significantly upregulated Mcl1 but dose-dependently decreased Bax and cleavedcaspase-3 p17 (c). ^∗𝑃<0.001 versus sham group; ^◆𝑃<0.001 versus NS group; ^&𝑃<0.001 versus low-dose group.

(a)

(b)

(c)