Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD

Table 3

Clinical and inflammatory outcomes according to the severity of airflow obstruction in patients with COPD. Data are median (q1, q3) unless indicated.

	Moderate COPD	Severe COPD	𝑃
𝑛	34	20
Age, mean (SD)	70.4 (7.3)	69.9 (7.9)	0.844
Sex, male/female	16/28	9/11	0.555
Smoker, never/ex	12/22	3/17	0.096
Pack years	32.3 (17, 46.6)	37.3 (19.5, 53.8)	0.444
FEV1% predicted	65.3 (57.9, 69.8)	43.8 (38.2, 46.8)	<0.001
ICS dose	2000 (1000, 2000)	2000 (2000, 2000)	0.183
TLR4 mRNA	0.15 (0.12, 0.18), 𝑁=26	0.16 (0.11, 0.22), 𝑁=12	0.648