The Role of Glucocorticoid Receptors in Dexamethasone-Induced Apoptosis of Neuroprogenitor Cells in the Hippocampus of Rat Pups
Figure 5
Dexamethasone-(Dex-) induced apoptosis in P1 D1D2 pups was reduced by preadministration of RU486. Dex treatment increased apoptotic cell counts in the hippocampus compared to control (, *); P1 D1D2 pups treated with DMSO or DMSO plus Dex showed results similar to those from pups treated with either normal saline (NS) or Dex alone (, ). RU486 treatment showed apoptotic cell counts similar to those from pups treated with NS or DMSO. Pups treated with RU486 plus Dex had lower apoptotic cell counts than those with Dex or DMSO plus Dex (, †). P1 D1D2: P1 pups receiving treatment on postnatal day 1 and sacrificed on day 2.
