Characterization of Macrophage Phenotypes in Three Murine Models of House-Dust-Mite-Induced Asthma
Figure 4
(a) HDM-exposed male () and female () mice had more CD68-positive cells in lung tissue as compared to control, but no differences were found between the HDM protocols. Combining all models, HDM exposure induced higher numbers of CD68-positive cells in females than in males (). (b) HDM-exposed male and female mice had more IRF5-positive cells in lung tissue as compared to control, but no differences were found between males and females when combining all models. The 14-day HDM protocol induced higher numbers of IRF5-positive cells as compared to the 24-day HDM protocol. (c) HDM-exposed male and female mice had more YM1-positive cells in lung tissue as compared to control, with higher numbers of YM1-positive cells in females than in males (). The 24-day HDM protocol induced higher numbers of YM1-positive cells as compared to the 14-day HDM protocol. (d) HDM-exposed male and female mice had lower numbers of IL-10-positive cells in lung tissue as compared to control, but no differences were found between the HDM protocols and between the sexes. The middle and right-hand panels are representative photos of control and HDM-exposed mice for all four stainings (magnification 200x). #, ## and ### compared to control. *.
