Downregulation of NOX4 Expression by Roflumilast N-Oxide Reduces Markers of Fibrosis in Lung Fibroblasts
Figure 7
Effect of 8-epi-PGF2α and RNO on NOX4 expression in HLF. Cells from 3 separate donors were preincubated or not with RNO (2 nM) and then treated for 24 h with 8-epi-PGF2α (10−8 M). (a) Protein expression of NOX4 was analyzed by Western blotting. (b) Quantification of protein was expressed as a ratio to β-actin. Data are mean SD of 3 experiments. versus control (C); versus BLM.
