Proteinase-Activated Receptor-1 and Immunomodulatory Effects of a PAR1-Activating Peptide in a Mouse Model of Prostatitis
Figure 2
Cytokine production is elevated when ethanol + dinitrobenzene sulfonic acid is administered in wild-type mice. Prostates were treated with sterile saline (saline) or ethanol + dinitrobenzene sulfonic acid (EtOH + DNBS) for 2 days. The inflammatory response was measured by monitoring (a) interleukin-6 (IL-6), (b) interleukin-1β (IL-1β), (c) keratinocyte-derived cytokine (KC), and (d) tumor necrosis factor- (TNF-). Data are mean ± SEM of –6 per group. * for EtOH + DNBS versus saline.