Resolution of PMA-Induced Skin Inflammation Involves Interaction of IFN- and ALOX15
Figure 5
Application of LXA4 obtained a pro-resolution effect, while blocking LXA4 reverted the effect of IFN- neutralization. Three hours after the third PMA painting, mice were divided into 5 groups: control, anti-IFN-, LXA4, anti-IFN- and LXA4, and BOC2 and anti-IFN-. The skin tissues were removed 4 days after the third PMA treatment. Epidermal thickness (a) was analyzed by HE staining as described in Methods. The MCP-1 expression level (b) in the skin was detected by CBA. , compared to control group.
