Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice

Figure 10

Effects of DEC on carrageenan-induced COX-2 expression in the lung. Basal expression of COX-2 was detected in lung samples from the sham group, whereas COX-2 levels were substantially elevated in lung tissue obtained from animals 4 h after carrageenan injection. DEC treatment reduced the expression of COX-2, but treatment with indomethacin did not decrease the levels of COX-2 (a) and (b). (a) Representative blot of lysates obtained from pool 4 animals per group; (b) data expressed as mean ± S.E.M. of 4 replications for each group; ^∗𝑃<0.05 versus carrageenan; ^∘𝑃<0.05 versus DEC.