Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome

Table 1

Clinical characteristics of patients.

Characteristics	Control	SAP	UAP	AMI
	(𝑛=65)	(𝑛=50)	(𝑛=75)	(𝑛=67)
Age (years)	62.2±8.8	64.3±12.1	64.0±11.2	62.6±10.5
Sex (male/female)	47/18	35/15	50/25	48/19
Hypertension, 𝑛 (%)	41 (63.1)	29 (58)	46 (61.3)	41 (61.2)
Diabetes, 𝑛 (%)	16 (24.6)	14 (28)	29 (38.7)	25 (37.3)
Smoking, 𝑛 (%)	21 (32.3)	20 (40)	36 (48)	24 (35.8)
TC (mmol/L)	4.47±0.93	4.09±0.95	4.37±1.28	4.34±0.87
TG (mmol/L)	1.47±0.72	1.68±0.91	2.00±1.56^∗	1.58±0.99
LDL-C (mmol/L)	2.75±0.85	2.43±0.88	2.62±1.20	2.69±0.87
HDL-C (mmol/L)	1.32±0.61	1.17±0.42	1.21±0.58	1.02±0.33^∗
GLU (mmol/L)	5.49±1.50	5.68±2.19	6.60±3.40	6.64±2.76
Creatinine (𝜇mol/L)	76.93±16.68	92.14±28.69^∗	95.84±34.62^∗	94.01±38.89^∗
CRP (mg/L)	1.80±1.22	2.34±1.37	4.67±5.12	6.73±5.23
NT-proBNP (pg/mL)	106.1±44.0	168.4±58.2	365.5±172.2	729.1±326.5
LVEF (%)	65.7±5.0	60.4±8.7^∗	58.4±10.2^∗	45.9±10.5^∗
LVEDD (mm)	46.7±3.2	49.5±6.9	49.8±6.7^∗	55.1±5.9^∗
Gensini score	0	30.03±25.14^∗	32.65±26.05^∗	69.33±54.91^∗
Medications, 𝑛 (%)
Aspirin	12 (18.5)	25 (50)	60 (80)	38 (56.7)
𝛽-blocker	15 (23.1)	18 (36)	29 (38.7)	23 (34.3)
ACEI/ARB	32 (49.2)	20 (40)	35 (46.7)	35 (52.2)
CCB	37 (56.9)	25 (50)	48 (64)	18 (26.9)
Nitrate	21 (32.3)	26 (52)	58 (77.3)	31 (46.3)
Statin	19 (29.2)	32 (64)	54 (72)	31 (46.3)

The data are given as the mean ± SD or number of patients. SAP: stable angina pectoris; UAP: unstable angina pectoris; AMI: acute myocardial infarction; TC: total cholesterol; TG: total triglycerides; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; GLU: fasting glucose; LVEF: left ventricular ejection fraction; ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin receptor blocker; CCB: calcium channel blocker.
^∗𝑃<0.05 versus control.