Acute Exercise-Induced Response of Monocyte Subtypes in Chronic Heart and Renal Failure

Figure 2

Magnitude of the exercise-induced effect on monocyte count, monocyte subsets, and serum MCP-1 and IL-6 levels. (a) Following peak exercise, absolute monocyte count increased significantly in all groups. (b–d) Within the total monocyte count, the percentage of Mon1 decreased in all three groups with a parallel increase in Mon2 and Mon3 (with exception of Mon2 in CHF). Between-group analysis revealed that the overall response of the monocyte subsets was comparable between HS and CKD but was significantly blunted for patients with CHF ( for interaction <0.05 for all subsets). (e) Following peak exercise, MCP-1 levels increased significantly in HS but remained unchanged in patients with CKD and CHF ( for interaction). (f) Increase in IL-6 levels were observed in all groups but failed to reach the level of significance (HS ; CKD ; CHF ). Changes in monocyte subset are expressed as % change from baseline. , , and .

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