Induction of Heme Oxygenase-1 with Hemin Reduces Obesity-Induced Adipose Tissue Inflammation via Adipose Macrophage Phenotype Switching

Figure 4

HO-1 induction reduces HFD-induced adipose tissue inflammatory responses. C57BL/6 mice were fed an HFD diet for 2 weeks with hemin injection 3 times per week (). (a) The body weight change and food intake were measured. (b) TNF-α, IL-6 levels, and (c) IL-4 and adiponectin levels were measured by ELISA. (d) Expression of a macrophage marker (CD68) and inflammatory molecules (p-JNK/JNK, IκBα, and NF-κB p65) in adipose tissue were detected by western blotting. Results are means ± SEM. , , , and (compared with HFD-vehicle control).

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