Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice

Figure 5

Effect of CHR on neurological deficit. The behavioral scores were significant reduced (^★𝑃<0.05 versus tMCAO and Vehicle, Mann-Whitney U test) (a). The infarct volume was reduced ^(☆𝑃<0.05 versus tMCAO, Vehicle and CHR-M, ^★𝑃<0.05 versus tMCAO and Vehicle) (b, c). The water content of ischemic hemisphere was reduced (^☆𝑃<0.05 versus tMCAO, Vehicle and CHR-M, ^★𝑃<0.05 versus tMCAO and Vehicle) (d). BBB permeability was ameliorated ^(★𝑃<0.05 versus tMCAO and Vehicle) (e, f).

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