Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice

Figure 7

Effect of CHR on protein expression of NALP3, ASC (a), caspase-1, active caspase-1 (b), pro IL-1β and active IL-1β (c). For NALP3, active caspase-1 and active IL-1β, ^★𝑃<0.05, ^◆𝑃<0.05 and ^■𝑃<0.05 versus tMCAO and Vehicle (d). Bar graph of immunohistochemistry illustrating the expression of NALP3 (^☆𝑃<0.05 versus tMCAO, Vehicle and CHR-M, ^★𝑃<0.05 versus tMCAO, Vehicle), ASC, caspase-1 (^◊𝑃<0.05 versus tMCAO, Vehicle and CHR-M, ^◆𝑃<0.05 versus tMCAO, Vehicle) and IL-1β (^■𝑃<0.05 versus tMCAO and Vehicle) (e). Bar graph illustrating CHR reduced to mRNA of NALP3, caspase-1 and IL-1β (^★𝑃<0.05, ^◆𝑃<0.05 and ^■𝑃<0.05 versus tMCAO and Vehicle) (f).

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