Roles of 5-Lipoxygenase and Cysteinyl-Leukotriene Type 1 Receptors in the Hematological Response to Allergen Challenge and Its Prevention by Diethylcarbamazine in a Murine Model of Asthma

Figure 2

Effect of 5-LO deficiency on the in vivo priming of bone-marrow precursors for increased response to IL-5 ex vivo. PAS and ALOX mice were sensitized with OVA and challenged i.p. Bone-marrow was collected 48 h after challenge and cultured. Data (mean + SEM) are the numbers of EPO+ cells produced in culture with IL-5, 1 ng/mL, for 7 days, from bone-marrow of the indicated experimental groups (). All significant differences are indicated.