Roles of 5-Lipoxygenase and Cysteinyl-Leukotriene Type 1 Receptors in the Hematological Response to Allergen Challenge and Its Prevention by Diethylcarbamazine in a Murine Model of Asthma

Figure 3

Effect of MK886 on eosinophilia of bone-marrow. BALB/c mice sensitized to OVA were pretreated with vehicle (VEIC, methylcellulose 0,1%) or MK886, 1 mg/Kg, by intragastric administration (500 μL), 24 h and 1 h before challenge by aerosol (a), or by i.p. injection (b). Bone-marrow was collected 24 h (a) or 48 h (b) after challenge. Data (mean + SEM; (a), /5/13; (b), /5) are the number of EPO+ cells in freshly collected femoral bone-marrow after aerosol (a) or i.p. (b) challenge. All significant differences are indicated.

(a)

(b)