Protective Effect of Laminaria japonica with Probiotics on Murine Colitis

Figure 4

(a) Effects of LJE or DUO on histological findings in DSS-induced colitis. (a)-(A): normal, (a)-(B): control, (a)-(C): LJE 100, (a)-(D): LJE 300, (a)-(E): DUO, (a)-(F): DUO + LJE 100, (a)-(G): DUO + LJE 300, chevron: normal crypt, down arrow: cryptal damage, notches right arrow: infiltration of inflammatory cell, and reversed triangle: ulcer. The whole colon tissues were stained by (H) and (E). The center was the distal part and the boundary was the proximal part of colon (×20). (b) Effects of LJE or DUO on histological scores in DSS-induced colitis. Nor: normal mice without any treatment, Con: mice provided with only 5% DSS treatment, LJE: the water extract of Laminaria japonica, DUO: Duolac7S, LJE + DUO: cotreatment of LJE and DUO, 100: the dosage of LJE 100 mg/kg, and 300: the dosage of LJE 300 mg/kg; ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001 versus control group analyzed by one-way ANOVA with Dunnett’s post hoc test.