Reduction of IL-17A Might Suppress the Th1 Response and Promote the Th2 Response by Boosting the Function of Treg Cells during Silica-Induced Inflammatory Response In Vitro
Figure 4
The function of Treg cells might be boosted by anti-IL-17A mAb and IL-1Ra. ((a) and (b)) The secretion of IL-10 and TGF-β in supernatant of the macrophage-lymphocyte cocultured system was assayed by ELISA. ((c), (d), and (e)) The expressions of IL-10, TGF-β, and Foxp3 in lymphocytes were assayed by real-time PCR. The concentration of IL-1Ra is 15 μg/mL and the concentration of anti-IL-17A mAb is 20 μg/mL. Data were presented as mean ± SEM (). #: P<0.05, significantly different compared with the PBS group. Δ: P<0.05, significantly different compared with the silica group.
